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Image Search Results
Journal: Psychiatry research
Article Title: DNA methylation biomarkers prospectively predict both antenatal and postpartum depression
doi: 10.1016/j.psychres.2019.112711
Figure Lengend Snippet: a.)Plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for the originally published LDA model in women without a psychiatric history. b.)Plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for the SVM model in women without a psychiatric history. c.) Plot of EPDS threshold values (x axis) as a function of the mean model output (predicted probability) for women above the EPDS threshold minus that for women below the threshold (y axis) for the originally published LDA model in women without a psychiatric history. d.)Plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for the SVM model in women with a previous history of PPD. e.) Plot of EPDS threshold values (x axis) as a function of the mean model output for women above the EPDS threshold minus that for women below the threshold (y axis) for the SVM model in women with a previous history of PPD. f.)Plot of EPDS threshold values (x axis) as a function of the mean model output for women above the EPDS threshold minus that for women below the threshold (y axis) for the SVM model in women without a psychiatric history. g.) Plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for the novelly SVM model accounting for antenatal depression status in a combined sample of women with and without a previous history of PPD. h.)Plot of EPDS threshold values (x axis) as a function of the mean model output for women above the EPDS threshold minus that for women below the threshold (y axis) for the novelly SVM model accounting for antenatal depression status in a combined sample of women with and without a previous history of PPD. Horizontal dashed red lines denote an AUC of 70% while a dashed vertical black line denotes an EPDS of ≥ 13, signifying likely PPD.
Article Snippet: From a practical standpoint, in order to generate a model with the potential to be efficacious in a clinical environment, we trained a new
Techniques:
Journal: Psychiatry research
Article Title: DNA methylation biomarkers prospectively predict both antenatal and postpartum depression
doi: 10.1016/j.psychres.2019.112711
Figure Lengend Snippet: a.)Plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for the SVM model accounting for antenatal depression status in women from the UC Irvine cohort where antenatal depression status is determined with T1 time point biomarker output. b.)Plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for the SVM model accounting for antenatal depression status in the JHU Prospective Neuroimaging cohort. Horizontal dashed red lines denote an AUC of 70% while a dashed vertical black line denotes an EPDS of ≥ 13, signifying likely PPD. c.) A plot of EPDS threshold values (x axis) as a function of the AUC of prediction for the number of women above that threshold (y axis) for an SVM model to detect PPD status trained on a model incorporating variation in both TTC9B and HP1BP3 across three technical replicates in a subset of N = 20 women from the JHU Prospective Neuroimaging cohort. Horizontal dashed red lines denote an AUC of 80%.
Article Snippet: From a practical standpoint, in order to generate a model with the potential to be efficacious in a clinical environment, we trained a new
Techniques: Biomarker Discovery